2025
37. Synthesis of Selectively 13C/2H/15N-Labeled Arginine to Probe Protein Conformation and Interaction by NMR Spectroscopy.
Eur. J. Chem. 2025, 31, 24, e202500408
D.I. Rohden, G. Toscano, P. Schanda, R.J. Lichtenecker
36. Synthesis of a 13C/2H Labeled Building Block to Probe the Phosphotyrosine Interactome Using Biomolecular NMR Spectroscopy.
ChemBioChem 2025, 26, 1, e202400663
S. Kratzwald, Thomas C. Schwarz, K. Ledolter, M. Hlavac, M. Felkl, C.F.W. Becker, R. Konrat, R.J. Lichtenecker
2024
35. The Synthesis of a Specifically Isotope Labelled Fluorotryptophan and its Use in Mammalian Cell-Based Protein Expression for 19F-NMR Applications.
G. Toscano, M. Rosati, L- Barbieri, K. Maier, L. Banci, E. Luchinat, R. Konrat, R.J. Lichtenecker
34. Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F-13C two-dimensional NMR.
RSC Chem. Biol. 2024, 5, 1214.
M. Suleiman, G.A. Frere, R. Törner, L. Tabunar, G.V. Bohle, K. Taverner, N. Tsuchimura, D. Pichugin, R.J. Lichtenecker, O. Vozny, P. Gunning, H. Arthanari, R.S. Prosser
33. Towards cost-effective-chain isotope labelling of proteins expressed in human cells.
M. Rosati, L. Barbieri, M. Hlavac, S. Kratzwald, R.J. Lichtenecker, R. Konrat, E. Luchinat and L. Banci
32. Probing Protein-Ligand Methyl-Pi Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups.
J. Med. Chem. 2024, 67, 15, 13187.
A. Beier, G. Platzer, T. Höfurthner, A.L. Ptaszek, R.J. Lichtenecker, L. Geist, J.E. Fuchs, D.B. McConnell, M. Mayer and R. Konrat
31. Exploring the pH dependence of an improved PETase.
C. Charlier, S. Gavalda, J. Grga, L. Perrot, V. Gabrielli, F. Löhr, J. Schörghuber, R. Lichtenecker, G. Arnal, A. Marty, V. Tournier, G. Lippens*
30. Decorating phenylalanine side-chains with triple labeled 13C/19F/2H isotope patterns.
G. Toscano, J. Holzinger, B. Nagl, G. Kontaxis, H. Kählig, R. Konrat, R.J. Lichtenecker*
29. 13Cβ-Valine and 13Cγ-Leucine Methine Labeling To Probe Protein Ligand Interaction.
ChemBioChem 2024, 25, 6, e202300762.
G. Toscano, T. Höfurthner, B. Nagl, A. Beier, M. Mayer, L. Geist, D.B. McConnell, H. Weinstabl, R. Konrat*, R.J. Lichtenecker*
2023
28. Synthesis of a 13C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics
T. Höfurthner, G. Toscano, G. Kontaxis, A, Beier, M. Mayer, L. Geist, DB. McConnell, H. Weinstabl, R. Lichtenecker*, R. Konrat*
27. E. coli "Stablelabel" S30 lysate for optimized cell-free NMR sample preparation
J. Biomol. NMR 2023, 77, 131-147.
R. Levin, F. Löhr, B. Karakoc, R. Lichtenecker, V. Dötsch, F. Bernhard
26. The rigid core and flexible surface of amyloid fibrils probed by Magic-Angle Spinning NMR of aromatic residues
Angew. Chem. Int. Ed. 2023, 62, 19, e202219314
L.M. Becker, M. Berbon, A. Vallet, A. Grelard, E. Morvan, B. Bardiaux, R. Lichtenecker, M. Ernst, A. Loquet, P. Schanda*
25. Aromatic ring flips in differently packed ubiquitin protein crystals from MAS NMR and MD
J. Struct. Biol.:X 2023, 7, 100079.
D.F. Gauto, O.O. Lebedenko, L.M. Becker, I. Ayala, R. Lichtenecker, N.R. Skrynnikov, P. Schanda
2021
24. The hydrogen1 R1rho relaxation dispersion experiments in aromatic side chains
J. Biomol. NMR 2021, 75, 383-392.
M. Dreydoppel, R.J. Lichtenecker, M. Akke, U. Weininger*
2020
23. PI by NMR: Probing CH-Pi Interactions in Protein-Ligand Complexes by NMR Spectroscopy.
Angew. Chem. Int. Ed. 2020, 59, 14861-14868.
G. Platzer, M. Mayer, A. Beier, S. Brueschweiler, J.E. Fuchs, H. Engelhardt, L. Geist, G. Bader, J. Schörghuber, R. Lichtenecker, B. Wolkerstorfer, D. Kessler, D.B. McConnell*, R. Konrat*
2019
22. Site-selective 1H/2H labeling enables artifact-free 1H CPMG relaxation dispersion experiments in aromatic side chains.
J. Biomol. NMR 2019, 73, 633-639.
H.N. Raum, J. Schörghuber, M. Dreydoppel, R.J. Lichtenecker, U. Weininger*
21. Aromatic ring dynamics, thermal activation and transient conformations of a 468 kDa enzyme by specific labeling and fast-MAS NMR.
J. Am. Chem. Soc. 2019, 141, 28, 11183-11195.
D.F. Gauto, P. Macek, A. Barducci, H. Fraga, A. Hessel, T. Terauchi, D. Gajan, Y. Miyanoiri, J. Boisbouvier, R.J. Lichtenecker, M. Kainosho, P. Schanda*
20. Futile encounter engineering of the DSR-M dextransucrase modifies the resulting polymer length.
Biochemistry 2019, 58, 25, 2853-2859.
Claverie M, Cioci G, Guionnet M, Schörghuber J, Lichtenecker R, Moulis C, Remaud-Simeon M*, Lippens G*
2018
19. Late metabolic precursors for selective aromatic residue labeling.
J Biomol NMR 2018, 71, 3, 129-140.
Schörghuber J, Geist L, Platzer G, Feichtinger M, Bisaccia M, Scheibelberger L, Weber F, Lichtenecker RJ*
2017
18. Anthranilic acid, the new player in the ensemble of aromatic residue labeling precursor compounds.
J Biomol NMR 2017, 69, 1, 13-22.
Schörghuber J, Geist L, Bisaccia M, Weber F, Konrat R, Lichtenecker RJ*
17. Highly selective stable isotope labeling of histidine residues using a novel precursor in E. coli-based overexpression systems.
ChemBioChem 2017, 18, 1487–1491.
Schörghuber J, Geist L, Platzer G, Konrat R, Lichtenecker RJ*
16. Bioactivity of topologically confined gramicidin A dimers.
Bioorg. Med. Chem. 2017, 25, 261-268.
Jadhav KB, Stein C, Makarewicz O, Pradel G, Lichtenecker RJ, Sack H, Heinemann SH, Arndt H-D*
2015
15. Synthesis of Metabolic Amino acid Precursors: Tools for Selective Isotope Labeling in Cell-Based Protein Overexpression.
Synlett 2015, 26, 2611-2616.
Lichtenecker RJ*, Schörghuber J, Bisaccia M
14. Novel approaches in selective tryptophan isotope labeling using Escherichia coli overexpression media.
ChemBioChem 2015, 16, 5, 746-751.
Schörghuber J, Sara T, Bisaccia M, Schmid W, Konrat R, Lichtenecker RJ*
13. Dynamic combinatorial enrichment of polyconformational D-/L peptide dimers.
Chem. Eur. J. 2015, 21, 15, 5898-5908.
Jadhav KBǂ, Lichtenecker RJǂ, Bullach A, Bhubaneswar M, Arndt H-D* ǂ equal contribution
onlinelibrary.wiley.com/doi/10.1002/chem.201405413/full
2014
12. Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labeling.
Org. Biomol. Chem. 2014, 12, 7551-7560.
Lichtenecker RJ*
2013
11. α-Ketoacids as precursors for phenylalanine and tyrosine labelling in cell-based protein overexpression.
J. Biomol. NMR 2013 57(4): 327-331.
Lichtenecker RJ*, Weinhaeupl K, Schmid W, Konrat R
10. Independent valine and leucine isotope labeling in Escherichia coli protein overexpression systems.
J. Biomol. NMR 2013 57(3): 205-209.
Lichtenecker RJ*, Weinhaeupl K, Reuther L, Schoerghuber J, Schmid W, Konrat R
9. Iterative Antimicrobial Candidate Selection from Informed D-/L-Peptide Dimer Libraries.
ChemBioChem. 2013 14(18): 2492-2499.
Lichtenecker RJ, Ellinger B, Han H-M, Jadhav KB, Baumann S, Makarewicz O, Grabenbauer M, Arndt H-D*
8. Selective Isotope Labelling of Leucine Residues by Using α-Ketoacid Precursor Compounds.
ChemBioChem. 2013 14:818-21.
Lichtenecker RJ*, Coudevylle N, Konrat R, Schmid W
<2011
7. Biomimetic synthesis of azole- and aryl-peptide alkaloids.
Biomimetic Organic Synthesis (Edited by E. Poupon, B. Nay), Wiley 2011 1: 317-355.
Arndt H-D*, Lichtenecker R, Loos P, Milroy L-G
6. Application of various ionic liquids as cosolvents for chloroperoxidase-catalysed biotransformations.
Monatsh. Chem. 2009 140(5): 509-512.
Lichtenecker RJ, Schmid W*
5. Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.
J. Biomol. NMR 2008 42(2): 111-127.
Schedlbauer A, Auer R, Ledolter K, Tollinger M, Kloiber K, Lichtenecker R, Ruedisser S, Hommel U, Schmid W, Konrat R, Kontaxis G*
4. An Isolated Helix Persists in a Sparsely Populated Form of KIX under Native Conditions.
Biochemistry 2006 45(29): 8885-8893.
Tollinger M*, Kloiber K, Agoston B, Dorigoni C, Lichtenecker R, Schmid W, Konrat R
3. Simplification of protein NOESY spectra using bioorganic precursor synthesis and NMR spectral editing.
J. Am. Chem. Soc. 2004 126(17): 5348-5349.
Lichtenecker R, Ludwiczek ML, Schmid W, Konrat R*
2. Tuning of Redox Potentials for the Design of Ruthenium Anticancer Drugs – an Electrochemical Study of [trans-RuCl4L(DMSO)]- and [trans-RuCl4L2]- Complexes, where L = Imidazole, 1,2,4-Triazole, Indazole.
Inorganic Chemistry 2004 43(22): 7083-7093.
Reisner E, Arion VB*, Guedes da Silva MFC, Lichtenecker R, Eichinger A, Keppler BK*, Vadim Y, Pombeiro AJL*
1. Two novel trans-tetrachloro(dimethyl sulfoxide)azoleruthenate(III) complexes, their antiproliferative activity and the coordination mode of triazole in H2trz[RuCl4(dmso)(Htrz)]
Inorg. Biochem. 2003, 96, 1, 243.
Unfried P*, Reisner E, Fremuth M, Jakupec MA, Lichtenecker R, Arion VB, Keppler BK J.